Recent Publications

Journal Papers:


  1. M.A. Anastasio, T.P. Matthews, “Joint reconstruction of the initial pressure and speed of sound distributions from combined photoacoustic and ultrasound tomography measurements”, Inverse Problems. Accepted: Sep 2017. [In press].
  2. B. Kelly, T.P. Matthews, M.A. Anastasio, “Deep Learning-Guided Image Reconstruction from Incomplete Data”, eprint arXiv:1709.00584
  3. A. Zamir, C. Hagen, P. Diemoz, M. Endrizzi, F. Vittoria, Y. Chen, M.A. Anastasio, A. Olivo, “Recent advances in edge illumination tomography”, Journal of Biomedical Optics. [In press].
  4. K. Mitsuhashi, J. Poudel, T.P.Matthews, A. Garcia-Uribe, L.V. Wang and M.A. Anastasio, “A forward-adjoint operator pair based on the elastic wave equation for use in transcranial photoacoustic computed tomography”SIAM Journal on Imaging sciencesAccepted: May 2017. [In press].
  5. T.P. Matthews, K. Wang, C. Li, N. Duric, M.A. Anastasio, “Regularized Dual Averaging Image Reconstruction for Full-Wave Ultrasound Computed Tomography“, IEEE Trans. UFFC, Volume: 64, Issue: 5, 811-825, May 2017.
  6. J. Poudel, T.P. Matthews, L. Li, M.A. Anastasio, L.V. Wang; “Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method.J. Biomed. Opt. 0001;22(4):041018.  doi:10.1117/1.JBO.22.4.041018.
  7. Y. Lou, W. Zhou, T. P. Matthews, C. M. Appleton, M. A. Anastasio, “Generation of anatomically realistic numerical phantoms for photoacoustic and ultrasonic breast imaging,” J. Biomed. Opt. 22(4), 041015 (2017), doi: 10.1117/1.JBO.22.4.041015.
  8. Y. Chen, H. Guan, C. K. Hagen, A. Olivo, and M. A. Anastasio, “Single-shot edge illumination x-ray phase-contrast tomography enabled by joint image reconstruction,” Opt. Lett.  42, 619-622 (2017)


  1. H. Li, S. Dolly, H.C Chen, M.A. Anastasio, DA. Low, H.H. Li, J.M. Michalski, W.L. Thorstad, H. Gay, S. Mutic: “A Comparative Study Based on Image Quality and Clinical Task Performance for CT Reconstruction Algorithms in Radiotherapy“,  Journal of Applied Clinical Medical Physics. 2016 Jul 8;17(4).
  2. A.A. Appel, V. Ibarra, S.I. Somo, J.C. Larson, A.B. Garson III, H. Guan, J.P. McQuiling, Z. Zhong, M.A. Anastasio, E.C. Opara, E.M. Brey: “Imaging of Hydrogel Microsphere Structure and Foreign Body Response Based on Endogenous X-ray Phase Contrast“, Tissue Engineering, Part C, vol 22 number 11, 2016.
  3. Y. Lou, K. Wang, A.A. Oraevsky, M.A.Anastasio: “Impact of non-stationary optical illumination on image reconstruction in optoacoustic tomography“, Journal of the Optical Society of America A, 33(12): 2333-23472016.
  4. C. Huang, K. Wang, R. Schoonover, L.V. Wang, and M.A. Anastasio: ” Joint Reconstruction of Absorbed Optical Energy Density and Sound Speed Distributions in Photoacoustic Computed Tomography: A Numerical Investigation “, IEEE Transactions on Computational Imaging, 2.2, 136-149, 2016.
  5. Q. Xu, A. Sawatzky, T. Jun, D. Yang, and M.A. Anastasio: ” Accelerated Fast Iterative Shrinkage Thresholding Algorithms for Sparsity-Regularized Cone-Beam CT Image Reconstruction “, Medical Physics, 43; 1849, 2016.
  6. H-C Chen, S. Dolly, H. Li, B Fischer-Valuck, J Dempsey, S. Mutic, M.A. Anastasio, and H. Li. ” An Integrated-Model Driven Method for In-treatment Upper Airway Motion Tracking using Cine MRI in Head & Neck Radiation Therapy “, Medical Physics, 43.8, 4700-4710, 2016.
  7. S. Dolly, H-C Chen, M.A. Anastasio, S. Mutic, and H. Li: ” Practical Considerations for Noise Power Spectra Estimation for Clinical CT Scanners “, Journal of Applied Clinical Medical Physics, Vol. 17:3, 2016.
  8. V. Ibarra, A. Appel, E. Opara, M.A. Anastasio and E.M Brey: ” Evaluation of the Tissue Response to Alginate Encapsulated Islets in an Omentum Pouch Mode “, Journal of Biomedical Materials Research: Part A, Accepted, 2016.
  9. L. Li, J. Xia, G. Li, A Garcia-Uribe, Q. Sheng, M.A. Anastasio, and L.V. Wang: ” Label-free Photoacoustic Tomography of Whole Mouse Brain Structures Ex Vivo “, Journal of Neurophotonics, 3.3, 035001-035001. 2016.


1. Q. Sheng, K. Wang, M. P. Matthews, J. Xia, L. Zhu, L. V. Wang, and M. A. Anastasio, “A constrained variable projection reconstruction method for photoacoustic computed tomography without accurate knowledge of transducer responses,”Medical Imaging, IEEE Transactions on, in press, (2015).

2. S. A. Ermilov, R. Su, A. Conjusteau, T. Oruganti, K. Wang, F. Anis, M. A. Anastasio, A. A. Oraevsky, “Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research“, Ultrasonic Imaging , in press, (2015).

3. H. Guan, Q. Xu, A. B. Garson III, and M. A. Anastasio, “ Boundary-enhancement in propagation-based X-ray phase contrast tomosynthesis improves depth position characterization,” Physics in Medicine and Biology , 60 (8) N151, (2015).

4. K. Wang, T. P. Matthews, F. Anis, C. Li, N. Duric, and M. A. Anastasio. “ Waveform inversion with source encoding for breast sound speed reconstruction in ultrasound computed tomography“, Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions , 62 (3): 475-493, (2015).

5. A. A. Alyssa, J. C. Larson, A. B. Garson, H. Guan, Z. Zhong, B. B. Nguyen, J. P. Fisher, M. A. Anastasio, and E. M. Brey. “ X‐ray phase contrast imaging of calcified tissue and biomaterial structure in bioreactor engineered tissues“, Biotechnology and bioengineering , 112(3): 612-620, (2015).

6. H. Chen, J. Tan, S. Dolly, J. Kavanaugh, M. A. Anastasio, D. A. Low, H. Li et al. “ Automated contouring error detection based on supervised geometric attribute distribution models for radiation therapy: A general strategy “, Medical physics, 42(2): 1048-1059, (2015).


1. J. Xia; W. Chen; K. Maslov; M. A. Anastasio; L. V. Wang, “ Retrospective respiration-gated whole-body photoacoustic computed tomography of mice,” J. Biomed. Opt. 19 (1), 016003 (2014).

2. K. Mitsuhashi, K. Wang, and M.A. Anastasio, “Investigation of the far-field approximation for modeling a transducer’s spatial impulse response in photoacoustic computed tomography,” Photoacoustics, Volume 2, Issue 1, Pages 21–32 (2014).

3. C.O. Schirra, B. Brendel. M.A. Anastasio, and E. Roessl, “Spectral CT: a technology primer for contrast agent development,” Contrast Media & Molecular Imaging, Volume 9, Issue 1, pages 62–70, (2014).

4. K. Wang, R.W. Schoonover Su, A.A. Oraevsky, M.A. Anastasio, “Discrete Imaging Models for Three-Dimensional Optoacoustic Tomography using Radially Symmetric Expansion Functions,” Medical Imaging, IEEE Transactions on, vol.33, no.5, pp.1180,1193, (2014).

5. Q. Xu, A. Sawatzky, E. Roessl, M.A. Anastasio. and C.O. Schirra, “Sparsity-regularized image reconstruction of decomposed K-edge data in spectral CT,” Phys. Med. Biol., 59 N65 (2014).

6. K. Wang, J. Xia, C. Li, L.V. Wang,a and M.A. Anastasio, “Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography,” J. Biomed. Opt., 19(5), 056007 (2014).

7. A. Sawatzky, Q. Xu, C.O. Schirra, and M.A. Anastasio, “Proximal ADMM for Multi-Channel Image Reconstruction in Spectral X-ray CT,” Medical Imaging, IEEE Transactions on, vol.33, no.8, pp.1657,1668, (2014).

8. H. Li, L. Yu, M.A. Anastasio, H. Chen, J. Tan, H. Gay, J.M. Michalski, D.A. Low and S. Mutic, “Automatic CT simulation optimization for radiation therapy: A general strategy,” Med. Phys. 41, 031913 (2014);

9. G. Li, J. Xia, K. Wang, K. Maslov, M.A. Anastasio, L. V. Wang ,“Tripling the detection view of high-frequency linear-array-based photoacoustic computed tomography by using two planar acoustic reflectors”, Quantitative Imaging in Medicine and Surgery
, In press, 2014.


1. C.O. Schirra, E. Roessl, T. Koehler, B. Brendel, A. Thran, D. Pan, M.A. Anastasio, R. Proksa, “Statistical Reconstruction of Material Decomposed Data in Spectral CT,” IEEE Trans Med Imaging 32(7):1249-57 (2013)

2. A.A. Appel, M.A. Anastasio, J.C. Larson, E.M. Brey, “Imaging challenges in biomaterials and tissue engineering,” Biomaterials 34(28):6615-30 (2013)

3. A.A. Appel, C-Y Chou, J.C. Larson, Z. Zhong, F.J. Schoen, C.M. Johnston, E.M. Brey and M.A. Anastasio, “An initial evaluation of analyser-based phase-contrast X-ray imaging of carotid plaque microstructure,” Br J Radiol 86(1021):20120318 (2013).

4. K. Wang, C. Huang, Y Kao, C-Y Chou, A.A. Oraevsky, M.A. Anastasio, “Accelerating image reconstruction in three-dimensional optoacoustic tomography on graphics processing units ,” Med. Phys. 40, 023301 (2013).

5. C. Huang, K. Wang, L. Nie, L.V. Wang, M.A. Anastasio, “Full-Wave Iterative Image Reconstruction in Photoacoustic Tomography With Acoustically Inhomogeneous Media ,” Medical Imaging, IEEE Transactions on vol.32, no.6, pp.1097,1110 (2013).

6. A.B. Garson, E.W. Izaguirre, S.G. Price, M.A. Anastasio, “Characterization of speckle in lung images acquired with a benchtop in-line x-ray phase-contrast system,” Phys Med Biol. 58(12):4237-53 (2013).

7. J. Xia, C. Huang, K. Maslov, M.A. Anastasio, and L.V. Wang, “Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array,” Optics Letters, Vol. 38, Issue 16, pp. 3140-3143 (2013)


1. A.A. Appel, C-Y Chou, J.C. Larson, Z. Zhong, F.J. Schoen, C.M. Johnston, E.M. Brey and M.A. Anastasio, “Analyzer-based phase-contrast x-ray imaging of carotid plaque microstructure,” The American Journal of Surgery Volume 204, Issue 5 (2012).

2. A.M. Zysk, J.G. Brankov, M.N. Wernick and M.A. Anastasio, “Adaptation of a clustered lumpy background model for task-based image quality assessment in x-ray phase-contrast mammography,” Med. Phys. 39, 906 (2012).

3. A.M. Zysk, R.W. Schoonover, Q. Xu, and M.A. Anastasio, “A framework for computing the spatial coherence effects of polycapillary x-ray optics,” Opt. Express 20, 3975–3982 (2012).

4. C. Huang, L. Nie, R.W. Schoonover, L.V. Wang, M.A. Anastasio, “Photoacoustic computed tomography correcting for heterogeneity and attenuation,” J. Biomed. Opt., 17, 061211 (2012).

5. R.W. Schoonover, L.V. Wang, M.A. Anastasio, “A numerical investigation of the effects of shear waves in transcranial photoacoustic tomography with a planar geometry,” J. Biomed. Opt. 17, 061215 (2012).

6. J.S. Sandu, R.W. Schoonover, J.I. Weber, J. Tawiah, V. Kunin, M.A. Anastasio, “Transducer field imaging using Acoustography,” Adv. Acoust. Vib., 275875 (2012).

7. C. Huang, L. Nie, R.W. Schoonover, Z. Guo, C.O. Schirra, M.A. Anastasio, L.V. Wang, “Aberration correction for transcranial photoacoustic tomography of primates employing adjunct data,” J. Biomed. Opt. 17, 066016 (2012).

8. A.M. Zysk, A.B. Garson, Q. Xu, E.M. Brey, W. Zhou, J.G. Brankov, M.N. Wernick, J.R. Kuszak, and M.A. Anastasio, “Nondestructive volumetric imaging of tissue microstructure with benchtop x-ray phase-contrast tomography and critical point drying,” Biomedical Optics Express, 3, 1924-1932 (2012).

9. Q. Xu, E.Y. Sidky, X. Pan, M. Stampanoni, P. Modregger, and M.A. Anastasio, “Investigation of discrete imaging models and iterative image reconstruction in differential X-ray phase-contrast tomography,” Optics Express, 20, 10724-10749 (2012).

10. J. Xia, M.R. Chatni, K.I. Maslov, Z. Guo, K. Wang, M.A. Anastasio and L.V. Wang “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17, 050506 (2012).

11. K. Wang, R. Su, A.A. Oraevsky and M.A. Anastasio, “Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography,” Phys. Med. Biol., 57, 5399 (2012).

12. Alyssa A. Appel, Cheng-Ying Chou, Howard P. Greisler, Jeffery C. Larson, Sunil Vasireddi, Zhong Zhong, Mark A. Anastasio, Eric M. Brey, “Analyzer-based phase-contrast x-ray imaging of carotid plaque microstructure,” Br J Radiol, 204(5) 631-636 (2012).

13. A. Tamhane, K. Arfanakis, M.A. Anastasio, X. Guo, M. Vannier, J. Gao, “Rapid PROPELLER- MRI: A combination of iterative reconstruction and under-sampling,” J. Magn. Reson. Imaging, 36, 1241-1247, (2012).

14. Liming Nie, Xin Cai, Konstantin Maslov, Alejandro Garcia-Uribe, Mark A. Anastasio, Lihong V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt., 17(11), 110506 (Nov 02, 2012).

15. Kun Wang and Mark A Anastasio, “A simple Fourier transform-based reconstruction formula for photoacoustic computed tomography with a circular or spherical measurement geometry ,” Phys. Med. Biol., 57 N493, (2012).


1. M. Roumeliotis, R.Z. Stodilka, M.A. Anastasio, E. Ng and J.L. Carson, “Singular value decomposition analysis of a photoacoustic imaging system and 3D imaging at 0.7 FPS,” Optics Express, 19, 13405-13417 (2011).

2. R.W. Schoonover, M.A. Anastasio, “Image reconstruction in photoacoustic tomography involving layered acoustic media,” J. Opt. Soc. Am. A, 28, 1114–1120 (2011).

3. R.W. Schoonover, M.A. Anastasio, “Compensation of shear waves in photoacoustic tomography with layered acoustic media,” J. Opt. Soc. Am. A, 28, 2091–2099 (2011).

4. A. Appel, M.A. Anastasio, and E.B. Brey, “Potential for Imaging Engineered Tissues with X-ray Phase Contrast,” Tissue Engineering Part B: Reviews, 17, 321-330 (2011).

5. K. Wang, S.A. Ermilov, R. Su, H.P. Brecht, A.A. Oraevsky M.A. Anastasio, “An imaging model incorporating ultrasonic transducer properties for three-dimensional optoacoustic tomographyMedical Imaging, IEEE Transactions on, 30, 203-214, (2011).


1. E.Y. Sidky, M.A. Anastasio, and X. Pan, “Image reconstruction exploiting object sparsity in boundary-enhanced X-ray phase-contrast tomographyOptics Express, 18, 10404-10422 (2010).

2. M. Roumeliotis, R.Z. Stodilka, M.A. Anastasio, G. Chaudhary, H. Al-Aabed, E. Ng, A. Immucci and J.L. Carson, “Analysis of a photoacoustic imaging system by the crosstalk matrix and singular value decompositionOptics Express, 18, 11406-11417 (2010).

3. M.A. Anastasio, C.Y. Chou, A.M. Zysk, and J.G. Brankov, “Analysis of ideal observer signal detectability in phase-contrast imaging employing linear shift-invariant optical systems,” J. Opt. Soc. Am. A, 27, 2648-2659 (2010).

4. A.M. Zysk, R.W. Schoonover, P.S. Carney, M.A. Anastasio, “Transport of intensity and spectrum for partially coherent fields,” Opt. Lett., 35, 2239–2241 (2010).

5. E.Y. Sidky, M. A. Anastasio, and X. Pan, “Image Reconstruction Exploiting Object Sparsity in Boundary-Enhanced Phase-Contrast Tomography,” Optics Express, 18, pp. 10404-10422 (2010).

6. E. M. Brey, A. Appel, Y-C. Chiu, Z. Zhong, and M. A. Anastasio, “X-Ray Imaging of Poly(ethylene glycol) Hydrogels Without Contrast Agents,” Tissue Engineering  Part C: Methods, 16, 1597-1600 (2010).

Book Chapters:

1. Patrick La Rivière, Jin Zhang, and Mark A. Anastasio, “Image Reconstruction in Optoacoustic Tomography Accounting for Frequency-Dependent Attenuation,” Photoacoustic Imaging and Spectroscopy, edited by Lihong V . Wang, (CRC Press, 2009), pp. 145–154.

2. K. Wang and M. A. Anastasio, “Photoacoustic and thermoacoustic tomography: image formation principles,” Handbook of Mathematical Methods in Imaging, edited by Otmar Scherzer, (Springer, 2011), pp. 781-815.